Medical ozone therapy uses ozone (O₃) — an unstable, three-atom form of oxygen — in controlled therapeutic doses to support cellular oxygen utilization, antioxidant pathway activation, and immune modulation. At InfusaLounge in Allen, TX, ozone is offered in three forms: Major Autohemotherapy (MAH IV ozone), MAH combined with Ultraviolet Blood Irradiation (UVBI), and transdermal ozone sauna through our ReFire-O3 system. Ozone therapy is not FDA-approved for any medical condition and is offered as a complementary integrative therapy. Protocols are designed by Triny Nguyen, APRN under medical oversight from Phyllis J. Gee, MD, FACOG, with patient screening for contraindications including pregnancy and G6PD deficiency.
Ozone therapy has a public relations problem, and the problem isn’t the therapy. It’s that most people first hear the word ozone in the context of smog warnings or hole-in-the-atmosphere headlines. So when a friend mentions they’re doing ozone IV as part of recovery from long COVID, the immediate reaction is somewhere between confusion and alarm.
Let’s clear that up first. Medical ozone is dramatically different from the ozone in air pollution. The dose, the purity, and the delivery method bear almost no relationship to one another. What medical ozone is, when used correctly, is one of the most versatile tools in integrative medicine. Here’s what it actually does, the three ways we deliver it at InfusaLounge, and how to know which option fits your situation.
What Medical Ozone Actually Is
Ozone (O₃) is an unstable form of oxygen — three oxygen atoms instead of the two in the air you breathe. When ozone is introduced into the body in controlled medical doses, it triggers a cascade of biological responses that researchers have been documenting for decades.
A review in Medical Gas Research details the published mechanisms: improved cellular oxygen utilization, activated antioxidant defense pathways, modulated immune system function, improved circulation and microcirculation, support for the body’s natural detoxification of metabolic waste, and antimicrobial activity against viruses, bacteria, and fungi in laboratory studies.
In simple terms, ozone is a metabolic and immune signaling tool. It’s a foundational integrative therapy that compounds with regular use.
With that mechanism in mind, here’s how we deliver it.
Option 1: Major Autohemotherapy (MAH IV Ozone)
Major autohemotherapy is the gold-standard form of medical ozone delivery. The procedure takes about 45 to 60 minutes in our comfortable lounge, and it’s the option Triny most often discusses with patients dealing with the most challenging clinical pictures.
Here’s how it works. We draw a measured volume of your blood. The blood is mixed with a precise concentration of medical-grade ozone in a sterile vacuum bottle. Then the ozonated blood is returned to you intravenously.
MAH ozone is the option Triny most often discusses with patients dealing with persistent post-viral fatigue, chronic Lyme exposure, complex chronic inflammation, autoimmune conditions, and stubborn chronic infections. The CDC notes that approximately 30% of COVID-19 patients experience persistent post-viral symptoms — this is a population where integrative ozone protocols are increasingly part of the conversation, though ozone is not an FDA-approved treatment for long COVID or any other condition.
Option 2: UVBI — Ultraviolet Blood Irradiation
For more resistant clinical pictures, MAH ozone can be combined with UVBI — ultraviolet blood irradiation — for an amplified effect. After your blood is ozonated, it passes through a controlled UV light chamber before being returned to your bloodstream.
The combination of ozone and UVBI is more biologically active than either alone. UVBI adds light-activated oxidative effects on circulating pathogens, enhanced immune signaling, and additional support for oxygen-carrying capacity in red blood cells.
At InfusaLounge, we offer both ozone alone and the ozone+UVBI combination. Triny will recommend which is appropriate based on what you’re working on. UVBI is typically reserved for patients with more entrenched chronic patterns where the additional intensity is clinically warranted.
Option 3: Ozone Sauna with the ReFire-O3 System
The third option is the one most new patients start with, because it’s the most approachable. Our ReFire-O3 ozone sauna delivers ozone transdermally through the skin in a 30-minute session, combined with several supporting modalities running in parallel.
A session works like this. You sit in the chamber with your head outside the entire time, so you’re never inhaling ozone. Your body sweats out metabolic waste and absorbs the therapeutic stack through your skin while five therapies run together:
- Transdermal ozone — ozone penetrates the skin and is absorbed systemically
- Carbonic acid therapy — supports tissue oxygenation
- PEMF (pulsed electromagnetic field) — cellular energy support
- Hydrogen inhalation — molecular hydrogen for antioxidant signaling
- LED light therapy — built into the chamber
The ozone sauna is the option Triny most often discusses with patients focused on general detoxification, athletic recovery, stress and HPA-axis support, and weekly wellness maintenance. It’s non-invasive, comfortable, and tends to produce noticeable effects on energy and recovery within the first few sessions.
Which Ozone Option Is Right for You?
With three options on the table, the obvious question is which one fits your situation. The short answer: MAH IV ozone is most often discussed with patients dealing with active clinical complexity. The ozone sauna is the entry point for wellness, detoxification, and athletic recovery. MAH combined with UVBI is reserved for the most resistant clinical patterns.
MAH IV ozone is the option Triny most often discusses with patients dealing with persistent post-viral fatigue, chronic Lyme exposure, autoimmune patterns, stubborn inflammation that hasn’t responded to other approaches, or significant immune dysregulation.
MAH + UVBI is the option for the same general population, but for patients whose situation calls for a more intensive approach. Often used during acute episodes of chronic conditions.
The ozone sauna is the option most patients start with. It’s the right fit for general detoxification support, athletic recovery, stress recovery, a non-invasive entry to ozone therapy, or as a regular weekly therapy that compounds over time.
Many of our regular patients combine approaches — a monthly MAH ozone IV plus a weekly ozone sauna is a common rhythm. Triny will help you design the right combination based on what you’re actually trying to accomplish.
What to Expect at Your First Session
If you’ve never done ozone therapy before, knowing what to expect helps. For first-time MAH ozone IV patients, plan on 60 to 90 minutes in the clinic total — 45 to 60 minutes for the actual procedure and a buffer for setup and observation. Some patients feel mild detox effects in the 24 hours after, ranging from slightly tired to noticeably energized, and most report a meaningful difference in energy and clarity by day 3 to 5.
For first-time ozone sauna patients, plan on 30 to 40 minutes total. You’ll sweat during the session, and you’ll feel a pleasant warmth and relaxation afterward. Most patients notice energy benefits within the same day.
If you’re new to ozone, Triny generally recommends starting with the sauna. It’s the most approachable entry point and lets you experience how your body responds before progressing to IV protocols. We always recommend extra hydration after any ozone session — your body has work to do afterward and water makes that work easier.
Frequently Asked Questions
Is ozone therapy safe?
When administered medically with appropriate dosing, medical-grade equipment, and proper patient screening, ozone therapy has a strong safety record in clinical practice. Medical ozone is fundamentally different from environmental ozone or industrial ozone — the dose, the delivery method, and the patient screening process are tightly controlled. That said, ozone therapy is not FDA-approved for any medical condition, and the FDA classifies it as a complementary therapy. Dr. Gee provides medical oversight on every ozone protocol, and Triny screens every new patient before any ozone session.
Are there contraindications to ozone therapy?
Yes, and we screen for them carefully. Pregnancy, G6PD deficiency, and certain blood disorders are contraindications. Patients on certain medications may need adjustments before starting. Active hyperthyroidism and a few other conditions also require careful evaluation. Triny will walk through your full medical history at consultation before recommending any protocol.
How often should I do ozone therapy?
It depends on what you’re working on. For more active clinical pictures, often weekly or twice weekly for the first 4 to 8 weeks. For wellness maintenance, once or twice a month. The ozone sauna is appropriate for weekly use indefinitely. Triny will design a protocol that fits your situation.
Is ozone therapy covered by insurance?
Generally no. Ozone therapy is considered a complementary integrative therapy and is not covered by most insurance plans. Most patients self-pay.
Does the ozone sauna feel like a regular sauna?
It’s a wet-heat sauna, similar in general feel to a steam room, with ozone delivery to your skin. Most patients find it comfortable and relaxing. The 30-minute session passes quickly.
Can I combine ozone with other InfusaLounge therapies?
Yes, and many patients do. NAD+ IV therapy, vitamin and amino acid IVs, B12 injections, and our other wellness protocols all combine well with ozone. Triny coordinates everything under one treatment plan.
Ready to Try Ozone?
Most of our new ozone patients start with a sauna session — easy, comfortable, no needles. Once you experience how your body responds, you and Triny can decide whether to move into IV protocols.
InfusaLounge Integrative & Functional Medicine
190 E Stacy Rd #1720, Allen, TX 75002
Call 972-546-4318 or book your first ozone session
Serving Allen, McKinney, Frisco, Plano, and surrounding North Dallas communities.
About the Authors
Medically reviewed by Phyllis J. Gee, MD, FACOG. Dr. Phyllis J. Gee is Medical Director of InfusaLounge Integrative & Functional Medicine. A board-certified OB/GYN and Fellow of the American College of Obstetricians and Gynecologists, she completed her Bachelor of Science in Nutrition at Cornell University, her MD at Wayne State University School of Medicine, and her residency in Obstetrics and Gynecology at Albert Einstein College of Medicine. She is an ADAPT-trained Functional Medicine practitioner (Kresser Institute) with more than 30 years of clinical experience. Dr. Gee’s research on transcervical fibroid ablation has been published in the International Journal of Gynecology and Obstetrics, and she served as a site investigator in the FDA-reviewed SONATA Pivotal IDE clinical trial. She has been cited in The New York Times. NPI 1417953241 · Texas Medical License H1583. View full bio →
Written by Melissa Chester, BBA. Founder and Director of Operations, InfusaLounge Integrative & Functional Medicine. Healthcare operations leader who built InfusaLounge from the ground up in 2018, with direct operational oversight of every clinical program. View full bio →
